Table 1.

Novel protein components of the mammalian Chromatoid body (see [1] for a list of previously identified CB proteins and [29] for the most updated full RNA and protein composition of the CB).

Protein	Synonym	Description	Function	Ref
BASP1 and MARCKS	NAP-22 for BASP1	Brain Acid Soluble Protein 1 and Myristoylated Alanin Rich C Kinase Substrate	In neurons; affect actin cytoskeleton dynamics and promote outgrowth	[27]
CLOCK and BMAL1	ARNT-like 1 for BMAL1	Circadian Locomoter Output Cycles protein Kaput and Brain and Muscle ARNT-Like 1	CLOCK and BMAL1 are central regulators of the circadian clock. Bmal1 KO and Clock KO mice display morfologic CB alterations due to BMAL1 ablation or low expression	[34]
HAT1 and p46	-	Histone acetyltransferase 1 and Histone-binding protein RBBP7	Hat1 and its cofactor p46 control the physiology of the CB by acetylation of MVH	[33]
MAGO	MAGOH; MGN2	Protein mago nashi homolog	Its role in normal spermatogenesis of vertebrates is unknown	[29, 104]
NANOS1 and PUMILIO2	-	Nanos homolog 1 and Pumilio homolog 2	NANOS1 and PUMILIO2 bind to regulate translation of specific mRNAs germ cells of certain model organisms	[105]
NONO	-	Non-POU domain containing; octamer binding protein	RNA binding protein. It may participate in various steps of mRNA processing and protein translation	[106]
NSun2	Misu	NOL1/NOP2/Sun domain family member 2	Cytosine-5 RNA methyltransferase. Nsun2 KO mice have male gametogenesios blocked at the pachytene stage	[107]
PABPC1 and PABPC3	-	Poly(A) Binding Protein; Cytoplasmic 1 and 3	Bind the poly(A) tail of mRNA. May be involved in cytoplasmic regulatory processes of mRNA metabolism.	[106, 108]
SAM68	-	KH domain-containing; RNA-binding; signal transduction-associated protein 1	RNA binding protein with potential role in the miRNA pathway during spermatogenesis	[29, 109]
SCaMC-1L	-	Small calcium-binding mitochondrial carrier protein 1 like	ATP-Mg/Pi carrier that mediate a reversible electroneutral exchange between ATP-Mg2- and HPO4 2- and control the net transport of adenine nucleotides across the inner mitochondrial membrane	[110]
TDRD9	-	Mouse Tudor repeat-9	Tudor domain containing protein that is essential for supressessing LINE1 retrotranpsosons. Tdrd9 KO mice have male gametogenesis blocked at zygotene stage	[29, 111]
TSSK1; TSSK2 and TSKS	-	Testis-specific serine/threonine-protein kinase 1; 2 and Testis-specific serine kinase substrate	Tssk1 and Tssk2 KO mice have male gametogenesis blocked at elongating spermatids possessing a collapsed mitochondrial sheath	[112]