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. Author manuscript; available in PMC: 2016 Oct 1.
Published in final edited form as: Curr Opin Plant Biol. 2015 Jul 31;27:118–124. doi: 10.1016/j.pbi.2015.06.012

Figure 2.

Figure 2

Alternative models for hc-siRNA/target interactions. Model 1: AGO4-bound hc-siRNAs identify target sites on nascent Pol V RNAs, but don’t cleave them. Model 2: AGO4-bound hc-siRNAs identify target sites in genomic DNA within the Pol V transcription bubble. Model 3: Like model 1, except that AGO4 catalyzes slicing of the Pol V RNA.