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. Author manuscript; available in PMC: 2017 Jan 9.
Published in final edited form as: Dev Growth Differ. 2016 Jan 9;58(1):88–93. doi: 10.1111/dgd.12259

Fig. 1. Temporal regulation of neuronal connectivity by the lin-4-lin-14 pathway.

Fig. 1

(A) The AVM axon initially projects ventrally towards the ventral nerve cord, guided by the repulsive SLT-1 and the attractive UNC-6 guidance cues. The highest level of lin-4 expression occurs when the axon reaches its most anterior position. At this point, the axon no longer responds to UNC-6 attractive guidance cues in the ventral nerve cord and projects dorsally to form synapses. (B) Temporal control of transition from axon pathfinding to synapse formation by lin-4 miRNA functioning through the unc-6 signaling.