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. Author manuscript; available in PMC: 2016 Jul 8.
Published in final edited form as: Mod Pathol. 2016 Jan 8;29(2):157–165. doi: 10.1038/modpathol.2015.148

Figure 2. Identification of two clonally distinct tumor foci on discontinuously involved prostate needle biopsy cores by dual ERG/SPINK1 immunohistochemistry.

Figure 2

H&E staining identifies two separate tumors that discontinuously involve 80% of one core in these 2 cases. Immunohistochemistry staining shows discordant ERG/SPINK1 status between foci (ERG, brown chromogen, nuclear localization; SPINK1, red chromogen, cytoplasmic localization). A. One focus is ERG+/SPINK− (right) and the other one is ERG−/SPINK1− (left) B. One focus is ERG−/SPINK1+ (right) and the other is ERG−/SPINK1− (left), consistent with distinct clonal origin. Original images from whole slide imager scanned slides; insets of solid and dashed black boxes shown at higher magnification.