. Author manuscript; available in PMC: 2016 Jul 8.

Published in final edited form as: Mod Pathol. 2016 Jan 8;29(2):157–165. doi: 10.1038/modpathol.2015.148

Table 2.

Pathological parameters of multiclonal biopsies as supported by discordant ERG/SPINK1 IHC (n=24)

Gleason Score	n (%)

6	13 (54%)
3+4	5(21%)
4+3	4 (17%)
>7	2 (12%)

Maximum Tumor Involvement %

Median (range)	78% (20%–100%)
<50% Involvement, n (%)	2 (8%)
≥50% Involvement, n (%)	22 (92%)

Discordant IHC pattern	n (%)

ERG⁺/SPINK1⁻ and ERG⁻/SPINK1⁻	14 (58%)
ERG⁻/SPINK1⁺ and ERG⁻/SPINK1⁻	7 (29%)
ERG⁺/SPINK1⁻ and ERG⁻/SPINK1⁻	3 (13%)

Pathological parameters for the 24 (25%) multiclonal discontinuously involved prostate biopsy cores (of 97 assessed) as determined by discordant dual ERG/SPINK1 immunohistochemistry (IHC). Gleason score, maximum % tumor involvement (inclusive of intervening benign tissue) and ERG/SPINK1 status of the two discordant foci are provided for each core.