Injection with neurokinin 1 receptor antagonists into the anterior paraventricular thalamus (aPVT) significantly reduces ethanol drinking (Experiment 2). A L-733,060 (0.5, 5.0 nmol in 0.3 μl) compared to saline vehicle significantly reduces intermittent-access 20% ethanol drinking with injection into the aPVT (n = 10), but not into the posterior paraventricular thalamus (pPVT, n = 10). B Injection of RP 67580 (0.5, 5.0 nmol in 0.3 μl) compared to dimethyl sulfoxide vehicle significantly reduces intermittent-access 20% ethanol drinking with injection into the aPVT (n = 10), but not into the posterior paraventricular thalamus (pPVT, n = 10). Data are mean ± S.E.D.; *p < 0.05, #p = 0.06 vs. vehicle.