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. Author manuscript; available in PMC: 2018 Jan 1.
Published in final edited form as: Addict Biol. 2015 Jul 29;22(1):58–69. doi: 10.1111/adb.12288

Figure 6.

Figure 6

Injection of a neurokinin 1 receptor antagonist blocks orexin-induced ethanol drinking. Pretreatment with a sub-threshold dose of the neurokinin 1 receptor antagonist L-733,060 (0.5 nmol in 0.3 μl) compared to saline vehicle prevents the increase in intermittent-access 20% ethanol drinking induced by injection of orexin-B (OX-B, 1 nmol) into the anterior paraventricular thalamus (aPVT) as compared to saline vehicle. Neither L-733,060 at this dose nor OX-B alters ethanol drinking with injection into the posterior paraventricular thalamus (pPVT) (Experiment 7; N = 18, n = 9/group). Data are mean ± S.E.D.; *p < 0.05, #p = 0.06 vs. vehicle.