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. 2016 Jan 29;11(1):e0148155. doi: 10.1371/journal.pone.0148155

Fig 6. Selective deletion of PWCR only in NPY neurons.

Fig 6

In situ hybridisation for A.) NPY and B.) POMC expressions in arcuate nucleus of WT and PWCR KO mice. Bone phenotype analysis of PWCRf/f, NPYCre/+ and PWCRf/f control mice: C.) femur length; D.) whole body BMD; E.) whole body BMC measured by DXA; F.) cortical bone volume; G.) cortical thickness; H.) periosteal circumference and I.) endosteal circumference measured by μCT. n = 6–8 represented as mean ± SD using 16 week old male mice. J.) Serum IGF-1 levels and in situ hybridisation for K.) NPY and L.) POMC in the arcuate nucleus of PWCRf/f, NPYCre/+ and PWCRf/f control mice. n = 4–6 represented as mean ± SD using 16 week old male mice. * p-value<0.05, ** p-value<0.01, *** p-value<0.001.