Table 2. Semi-quantitative and quantitative CT perfusion (CTP) Alberta Stroke Program Early CT Score (ASPECTS) in 62 acute ischemic stroke patients categorized according to hemorrhagic transformation (HT) and clinical outcome.
HT (n = 27) | no HT (n = 35) | p value | mRS≤2 (n = 42) | mRS>2 (n = 20) | p value | |
---|---|---|---|---|---|---|
Semi-quantitative CTP ASPECTS | ||||||
CBF (median, IQR, mean ± SD, range) | 3, 1.5–4.5, 6.1±2.2, 2–9 | 6, 4.5–8, 3.3±2.4, 0–9 | p<0.0001* | 6, 3–8, 5.6±2.7, 0–9 | 4, 2–5, 3.5±2.2, 0–8 | p<0.01* |
CBV (median, IQR, mean ± SD, range) | 7, 6–9, 7.2±1.8, 3–10 | 9, 9–10, 9.2±1.0, 6–10 | p<0.00001^ | 9, 9–10, 8.8±1.4, 6–10 | 8, 6–8, 7.3±1.9, 3–10 | p<0.01^ |
MTT (median, IQR, mean ± SD, range) | 3, 2–5, 3.6±2.5, 0–9 | 6, 4–8, 6.0±2.4, 2–9 | p<0.001* | 6, 3–8, 5.6±2.7, 0–9 | 4, 2–5, 3.8±2.3, 0–8 | p<0.02* |
CTP mismatch (median, IQR, mean ± SD, range) | 4, 2–5, 3.6±2.0, 0–7 | 3, 1–5, 3.2±2.3, 0–8 | p = 0.488* | 1, 1–1, 1.0±0.5, 0–2 | 4, 2–5, 3.5±2.0, 0–6 | p = 0.686* |
Quantitative CTP ASPECTS | ||||||
CBF (median, IQR, mean ± SD, range) | 4, 2–6, 3.9±2.6, 0–9 | 7, 5–8, 6.5±2.2, 2–10 | p<0.0001* | 7, 4–8, 6.1±2.5, 1–10 | 4, 2–5, 3.8±2.4, 0–8 | p<0.001* |
CBV (median, IQR, mean ± SD, range) | 9, 7–9.5, 8.1±1.9, 4–10 | 10, 10–10, 9.6±0.9,6–10 | p<0.001^ | 10, 9–10, 9.3±1.1, 6–10 | 9, 7–10, 8.1±2.1,4–10 | p = 0.021^ |
MTT (median, IQR, mean ± SD, range) | 1, 0–3, 2.0±2.5, 0–9 | 6, 3–7, 5.1±2.5, 0–9 | p<0.0001* | 5, 2–7, 4.7±3.0, 0–9 | 2, 0–2, 1.7±1.7, 0–6 | p<0.001* |
CTP mismatch (median, IQR, mean ± SD, range) | 6, 4–8, 6.1±2.6, 0–10 | 4, 2,5–7, 4.5±2.6,0–10 | p = 0.021* | 1, 1–1, 1.0±0.5, 0–2 | 7, 5–8, 6.4±1.9, 4–10 | p<0.02* |
CBF = cerebral blood flow; CBV = cerebral blood volume; MTT = mean transit time; SD = Standard deviation; IQR = Interquartile range; mRS ≤ 2 = good outcome; mRS > 2 = poor outcome
statistical analysis = *t-test
^Mann-Whitney.