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. 2016 Feb 5;245:82–89. doi: 10.1016/j.cbi.2015.12.014

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© 2015 The Authors

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

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Fig. 1 — Acetylcholinesterase (AChE) activity in blood and rat brain regions 4 (A, n = 8 for each dose), 8 (B, n = 6–7 for each dose) and 24 h (C, n = 8 for each dose) after acute in vivo exposure to diazinon (i.p). AChE activity was affected by dose (F_(3,439) = 55.8, P < 0.001) and brain region (F_(5,439) = 12.8, P < 0.001) but not time since exposure with a significant dose*tissue interaction (F_(15,439) = 2.9, P < 0.001). Exposure to 13 and 39 mg/kg were significantly different to 0 mg/kg (P < 0.001) and the dorsal raphe nucleus (DRN) was significantly different to all other brain regions (P < 0.001) (Bonferroni post hoc tests). P < 0.05 compared to all (#) other brain regions (one-way ANOVA with Bonferonni post hoc tests for each dose) *P < 0.05 compared to 0 mg/kg (one-way ANOVA with Bonferonni post hoc tests for each region). Mean ± SEM. Cerebellum (CB), caudate putamen (CP), hippocampus (HP), prefrontal cortex (PFC).