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. 2015 Dec 9;157(2):570–585. doi: 10.1210/en.2015-1866

Figure 1.

Figure 1.

Liver lipid content is reduced in JAK2/CD36 DKO mice compared with JAK2L mice. CON, JAK2L, and JAK2/CD36 liver-specific KO mice (DKO) were fed a normal chow diet and samples collected at 9 weeks of age from ad libitum-fed mice. A, Hepatic Cd36 gene expression by quantitative RT-PCR and CD36 protein expression in liver by Western blot. B, Representative hematoxylin and eosin-stained liver sections from CON, JAK2L, and DKO mice at ×10 magnification. C, Plasma FFAs and TGs collected at 9 weeks (see also Table 1). D, Content of liver TG, DAG, CE, and ceramide content. E, Serum liver damage markers AST and ALT levels (n = 6–9/group). *, P < .05; **, P < .01; ***, P < .001; ****, P < .0001. F, Expression of F4/80, Mcp1, and Cd11b in the liver of CON, JAK2L, and DKO mice (n = 7–10/group); &, P < .001 compared with CON mice; b, P < .01, a, P < .001 compared with JAK2L mice. All data are shown as mean ± SEM.