Table 1.

Basic Metabolic Parameters in CON, JAK2L, and DKO Mice

	CON	JAK2L	DKO
Body weight, g	29.39 ± 1.25	25.99 ± 1.11	26.55 ± 0.62
Liver weight, g	1.35 ± 0.06	2.01 ± 0.21a	1.65 ± 0.08
Liver weight, %	4.60 ± 0.11	7.60 ± 0.45b	6.21 ± 0.23a,c
Body fat, %	18.38 ± 1.16	23.25 ± 2.20	19.55 ± 0.08
Lean mass, %	80.64 ± 1.25	77.13 ± 2.04	81.63 ± 0.56
Plasma FFA, mM	0.56 ± 0.05	0.63 ± 0.01	0.71 ± 0.03d
Plasma TG, mg/mL	0.63 ± 0.08	0.74 ± 0.11	0.75 ± 0.05
Glucose, mg/dL
Ad libitum fed	169.9 ± 10.7	157.0 ± 13.9	176.3 ± 14.1
Fasted	67.3 ± 6.1	118.5 ± 10.3b	98.9 ± 7.2d
Insulin, ng/mL
Ad libitum fed	0.354 ± 0.059	0.454 ± 0.061	0.736 ± 0.154
Fasted	0.034 ± 0.016	0.056 ± 0.025	0.029 ± 0.005
Liver glycogen, mg/g	30.09 ± 4.25	24.56 ± 2.70	44.86 ± 4.02c,d
Bilirubin, mg/dL	0.13 ± 0.02	0.08 ± 0.01	0.08 ± 0.01d

Data represents mean ± SEM.

^aP < .01 compared with CON.

^bP < .001 compared with CON.

^cP < .01 compared with JAK2L

^dP < .05 compared with CON.