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Kiss-10 is a putative substrate of EP24.15 based on in silico structural molecular modeling and substrate sequence similarity. A, The apoenzyme structure of EP24.15 (PDB ID, 1S4B) in an open conformation with the catalytic zinc highlighted in yellow. B, The apoenzyme structure with Kiss-10, highlighted in green, modeled into the active site cleft. C, Sequence similarities between known EP24.15 substrates and Kiss-10. Red plus signs (+) indicate cleavage sites.
