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. 2016 Jan 27;3(1):e195. doi: 10.1212/NXI.0000000000000195

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© 2016 American Academy of Neurology

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(A) Serostatus of 1,921 natalizumab-treated patients with multiple sclerosis, with JCV− patients shown in black and JCV+ patients in red. A total of 1,052 of these 1,921 patients were set as JCV+ (54.76%). (B) Serostatus of a longitudinally assessed cohort of 525 patients during 14.8 months of natalizumab treatment. (C) Serostatus of the German cohort of 339 initially JCV− patients (of 525 patients) before and after the period of observation (14.8 months of natalizumab treatment). Forty-three of these 339 patients (12.7%) were set as JCV+ after the period of observation. (D) Serostatus of the French cohort (n = 1,259; 711 longitudinally; BioNAT) of the 243 initially JCV− patients of 711, where all 3 time points were available, during their first 2 years of treatment. Twenty of these patients (8.2%) were set as JCV+ after the first year and an additional 21 (8.6%) after the second year of treatment, resulting in 41 of 243 patients (16.9%) changing their serostatus to JCV+ in the first 2 years of treatment. JCV = John Cunningham virus.