FIG 1.

Algorithm for the use of HCV Antigen assay in conjunction with the HCV RNA test for the accurate identification of actively replicating HCV based on the findings of this review and previously published work. *, for persons who might have been exposed to HCV within the past 6 months, testing for HCV RNA for follow-up testing for HCV antibody is recommended. For persons who are immunocompromised, testing for HCV RNA can be considered. †, to differentiate past, resolved HCV infection from biologic false positivity for HCV antibody, testing with another HCV antibody assay can be considered. Repeat HCV RNA testing if the person tested is suspected to have had HCV exposure within the past 6 months or has clinical evidence of HCV disease or if there is concern regarding the handling or storage of the test specimen.