Table 4.
List of 49 genes which may be implicated in disease (unique to the polyposis patients and not observed in the DGV). Note the gene symbol, description and if the gene is normally expressed in the colon (www.proteinatlas.org).
| Gene | Description | Expression |
|---|---|---|
| ADD3 | adducin 3 (gamma) | High |
| AIM1 | absent in melanoma 1 | Medium |
| AMICA1 | adhesion molecule, interacts with CXADR antigen 1 | Medium |
| ANKFN1 | ankyrin-repeat and fibronectin type III domain containing 1 | Not Detected |
| APC | adenomatous polyposis coli | Low |
| ARHGAP25 | Rho GTPase activating protein 25 | Low |
| ARHGAP26 | Rho GTPase activating protein 26 | Medium |
| ARHGDIB | Rho GDP dissociation inhibitor (GDI) beta | High |
| BCL2A1 | BCL2-related protein A1 | Low |
| BOD1L | biorientation of chromosomes in cell division 1-like 1 | Medium |
| C17orf95 | methyltransferase like 23 | Medium |
| C20orf199 | ZNFX1 antisense RNA 1 | Unknown |
| C5orf56 | chromosome 5 open reading frame 56 | Low |
| CCDC19 | coiled-coil domain containing 19 | Not Detected |
| CDH11 | cadherin 11, type 2, OB-cadherin (osteoblast) | Medium |
| CEACAM6 | carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) | High |
| DDX10 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 10 | Medium |
| ETV6 | ets variant 6 | Medium |
| FAM184B | family with sequence similarity 184, member B | Not Detected |
| FKBP1A | FK506 binding protein 1A, 12kDa | High |
| G0S2 | G0/G1switch 2 | Medium |
| GALC | galactosylceramidase | Medium |
| GAS7 | growth arrest-specific 7 | Medium |
| GPR65 | G protein-coupled receptor 65 | Low |
| HCN1 | hyperpolarization activated cyclic nucleotide-gated potassium channel 1 | Not Detected |
| HSD11B1 | hydroxysteroid (11-beta) dehydrogenase 1 | Low |
| JMJD6 | jumonji domain containing 6 | Medium |
| LAMB3 | laminin, beta 3 | Medium |
| LCA5 | Leber congenital amaurosis 5 | Low |
| MFSD11 | major facilitator superfamily domain containing 11 | Medium |
| MPZL3 | myelin protein zero-like 3 | Low |
| MXRA7 | matrix-remodelling associated 7 | Medium |
| NAMPT | nicotinamide phosphoribosyltransferase | Medium |
| NUMA1 | nuclear mitotic apparatus protein 1 | High |
| PLEK | pleckstrin | Medium |
| QKI | QKI, KH domain containing, RNA binding | Medium |
| RFT1 | RFT1 homolog (S. cerevisiae) | Medium |
| SELL | selectin L | Low |
| SFRS2 | arginine/serine rich splicing factor 2 | High |
| SH3BGRL2 | SH3 domain binding glutamic acid-rich protein like 2 | High |
| SMAP2 | small ArfGAP2 | Medium |
| SMC3 | structural maintenance of chromosomes 3 | Medium |
| SNORD12 | small nucleolar RNA, C/D box 12 | Unknown |
| SNORD12B | small nucleolar RNA, C/D box 12B | Unknown |
| SNORD12C | small nucleolar RNA, C/D box 12C | Unknown |
| STK17B | serine/threonine kinase 17b | Medium |
| STX8 | syntaxin 8 | High |
| TAGLN2 | transgelin 2 | High |
| ZNFX1 | zinc finger, NFX1-type containing 1 | Medium |