TABLE 1.
Age-standardized baseline characteristics according to quartiles of total iron intake in women with a history of GDM1
| Quartile of total iron intake |
|||||
| Characteristic | 1 | 2 | 3 | 4 | P-difference |
| Participants, n | 982 | 1005 | 995 | 994 | — |
| Age, y | 37.5 ± 4.62 | 37.7 ± 4.6 | 37.9 ± 4.5 | 37.6 ± 4.7 | 0.22 |
| Family history of diabetes, % | 29.0 | 27.2 | 26.8 | 22.6 | 0.01 |
| Race, Caucasian, % | 92.5 | 91.1 | 92.0 | 91.7 | 0.66 |
| Current oral contraceptive use, % | 8.4 | 9.1 | 9.2 | 8.5 | 0.97 |
| Current smoking, % | 14.4 | 12.5 | 9.1 | 7.4 | <0.001 |
| Alcohol, g/d | 2.7 ± 6.0 | 2.2 ± 4.5 | 2.2 ± 4.3 | 2.1 ± 4.3 | 0.02 |
| BMI, kg/m2 | |||||
| At baseline | 27.1 ± 6.7 | 27.4 ± 6.6 | 26.7 ± 6.1 | 26.1 ± 5.9 | <0.001 |
| At age 18 y | 21.2 ± 3.4 | 21.8 ± 3.7 | 21.4 ± 3.2 | 21.1 ± 3.2 | <0.001 |
| Physical activity, MET-h/wk | 16.1 ± 23.6 | 17.2 ± 24.4 | 16.9 ± 19.9 | 18.4 ± 23.2 | <0.001 |
| Total calories, kcal/d | 1847 ± 585 | 1928 ± 579 | 1995 ± 568 | 1851 ± 540 | <0.001 |
| Carbohydrates, energy, % | 47.7 ± 7.5 | 48.7 ± 7.2 | 50.9 ± 7.2 | 50.4 ± 7.8 | <0.001 |
| Total protein, energy, % | 18.6 ± 3.5 | 19.9 ± 3.4 | 19.5 ± 3.2 | 19.8 ± 3.6 | <0.001 |
| Total fat, energy, % | 34.2 ± 5.7 | 32.3 ± 5.6 | 30.9 ± 5.7 | 30.9 ± 5.9 | <0.001 |
| SFAs, energy, % | 12.4 ± 2.4 | 11.2 ± 2.3 | 10.7 ± 2.4 | 10.9 ± 2.5 | <0.001 |
| MUFAs, energy, % | 13.1 ± 2.5 | 12.4 ± 2.6 | 11.8 ± 2.6 | 11.8 ± 2.6 | <0.001 |
| PUFAs, energy, % | 5.8 ± 1.6 | 5.7 ± 1.4 | 5.6 ± 1.3 | 5.4 ± 1.5 | <0.001 |
| trans Fat, energy, % | 1.9 ± 0.7 | 1.7 ± 0.6 | 1.6 ± 0.6 | 1.5 ± 0.6 | <0.001 |
| Dietary cholesterol,3 mg/d | 250.1 ± 64.0 | 256.6 ± 73.0 | 240.5 ± 71.8 | 244.5 ± 75.8 | <0.001 |
| Total fiber,3 g/d | 15.6 ± 4.0 | 18.5 ± 4.7 | 19.9 ± 5.7 | 19.3 ± 5.6 | <0.001 |
| Cereal fiber,3 g/d | 4.3 ± 1.8 | 5.5 ± 2.1 | 6.5 ± 2.8 | 6.3 ± 3.2 | <0.001 |
| Fruit fiber,3 g/d | 2.9 ± 2.2 | 3.2 ± 2.1 | 3.5 ± 2.2 | 3.6 ± 2.2 | <0.001 |
| Vegetable fiber,3 g/d | 5.5 ± 2.4 | 7.1 ± 3.1 | 7.3 ± 3.7 | 6.8 ± 3.4 | <0.001 |
| Glycemic index3 | 53.7 ± 3.5 | 54.0 ± 3.2 | 53.9 ± 3.4 | 53.4 ± 3.6 | <0.001 |
| Glycemic load3 | 115.7 ± 21.8 | 118.4 ± 20.3 | 123.3 ± 21.1 | 121.6 ± 22.5 | <0.001 |
| Zinc,3 mg/d | 11.6 ± 4.8 | 13.0 ± 7.4 | 16.1 ± 9.5 | 25.6 ± 16.3 | <0.001 |
| Calcium,3 mg/d | 941.7 ± 409.7 | 935.0 ± 399.6 | 1042.3 ± 398.1 | 1256.5 ± 500.3 | <0.001 |
| Magnesium,3 mg/d | 271.5 ± 53.2 | 302.6 ± 58.8 | 338.0 ± 68.5 | 363.9 ± 92.7 | <0.001 |
| Potassium,3 mg/d | 2760.8 ± 536.0 | 2976.2 ± 512.1 | 3078.3 ± 578.8 | 3096.3 ± 583.0 | <0.001 |
| Vitamin E,3 mg/d | 17.7 ± 51.0 | 21.9 ± 54.7 | 24.8 ± 46.5 | 44.0 ± 86.4 | <0.001 |
| Vitamin C,3 mg/d | 167.1 ± 193.1 | 207.4 ± 252.2 | 248.8 ± 276.1 | 340.3 ± 383.4 | <0.001 |
| Folate,3 μg/d | 316.2 ± 163.2 | 361.3 ± 163.5 | 461.8 ± 163.3 | 749.4 ± 350.5 | <0.001 |
| Caffeine,3 mg/d | 221.7 ± 204.9 | 233.4 ± 214.8 | 208.4 ± 194.8 | 199.0 ± 201.5 | <0.001 |
| Red meat, servings/d | 1.1 ± 0.6 | 1.1 ± 0.7 | 1.0 ± 0.7 | 0.9 ± 0.6 | <0.001 |
| Poultry, servings/d | 0.4 ± 0.3 | 0.5 ± 0.3 | 0.5 ± 0.3 | 0.5 ± 0.3 | <0.001 |
| Fish, servings/d | 0.2 ± 0.2 | 0.2 ± 0.2 | 0.3 ± 0.2 | 0.2 ± 0.2 | <0.001 |
| Eggs, servings/d | 0.2 ± 0.2 | 0.2 ± 0.3 | 0.2 ± 0.2 | 0.2 ± 0.2 | 0.34 |
| Fruit, servings/d | 1.0 ± 0.9 | 1.2 ± 0.9 | 1.4 ± 1.1 | 1.3 ± 0.9 | <0.001 |
| Vegetables, servings/d | 2.8 ± 1.5 | 3.8 ± 2.1 | 4.1 ± 2.5 | 3.5 ± 2.1 | <0.001 |
| Nuts, servings/d | 0.3 ± 0.4 | 0.3 ± 0.4 | 0.3 ± 0.3 | 0.3 ± 0.4 | 0.36 |
| Legumes, servings/d | 0.3 ± 0.3 | 0.4 ± 0.3 | 0.5 ± 0.4 | 0.4 ± 0.4 | <0.001 |
| Whole grains, servings/d | 0.8 ± 0.8 | 1.1 ± 1.0 | 1.3 ± 1.1 | 1.2 ± 1.1 | <0.001 |
| Sugar-sweetened beverages, servings/d | 0.7 ± 1.1 | 0.4 ± 0.8 | 0.4 ± 0.8 | 0.4 ± 0.8 | <0.001 |
Baseline was defined as 1991 for prevalent GDM, and the year of the index pregnancy was used for incident GDM. All comparisons across quartiles of total iron intake were significant except for the following: age, race-ethnicity, current oral contraceptive use, and the consumption of eggs and nuts. GDM, gestational diabetes mellitus; MET-h, metabolic equivalent task hours.
Mean ± SD (all such values).
All values were energy adjusted.