TABLE 3.

Associations of anthocyanin, flavanone, and flavone intake with risk of erectile dysfunction across strata of risk factors for participants from the Health Professionals Follow-Up Study¹

	Q5 vs. Q1
	Flavones			Flavanones			Anthocyanins
	RR (95% CI)	P-trend	P-interaction	RR (95% CI)	P-trend	P-interaction	RR (95% CI)	P-trend	P-interaction
Age, y
<70	0.89 (0.81, 0.98)	0.002	0.002	0.87 (0.79, 0.96)	0.007	0.03	0.84 (0.77, 0.93)	<0.0001	0.007
≥70	1.06 (0.96, 1.16)	0.35		1.01 (0.91, 1.11)	0.99		1.04 (0.94, 1.14)	0.63
BMI, kg/m2
<25	1.06 (0.94, 1.18)	0.82	0.14	1.01 (0.90, 1.13)	0.99	0.009	1.04 (0.92, 1.16)	0.88	0.48
25–29.9	0.84 (0.76, 0.93)	0.004		0.87 (0.79, 0.96)	0.003		0.83 (0.75, 0.92)	0.0007
≥30	0.78 (0.65, 0.94)	0.005		0.69 (0.57, 0.83)	0.0002		0.89 (0.74, 1.07)	0.08
Smoking
Never	0.86 (0.78, 0.95)	0.005	0.26	0.87 (0.79, 0.96)	0.005	0.73	0.90 (0.81, 1.00)	0.03	0.80
Ever	0.94 (0.85, 1.03)	0.70		0.90 (0.82, 1.00)	0.04		0.91 (0.82, 1.00)	0.01
Physical activity
Q1 and Q2	0.94 (0.85, 1.05)	0.20	0.84	0.92 (0.83, 1.03)	0.04	0.55	0.95 (0.85, 1.06)	0.14	0.78
Q3	0.89 (0.80, 1.00)	0.07		0.86 (0.77, 0.96)	0.01		0.89 (0.80, 1.01)	0.03
Q4 and Q5	0.92 (0.78, 1.08)	0.23		0.93 (0.80, 1.09)	0.68		0.88 (0.75, 1.04)	0.21
Prevalent hypertension
No	0.97 (0.90, 1.05)	0.28	0.72	0.94 (0.87, 1.01)	0.06	0.86	0.93 (0.87, 1.01)	0.04	0.80
Yes	0.92 (0.79, 1.07)	0.14		0.91 (0.79, 1.06)	0.25		0.92 (0.79, 1.06)	0.19
Statin use
No	0.90 (0.83, 0.98)	0.02	0.71	0.89 (0.82, 0.96)	0.002	0.79	0.92 (0.84, 1.00)	0.01	0.78
Yes	0.90 (0.79, 1.03)	0.13		0.89 (0.78, 1.01)	0.09		0.91 (0.79, 1.04)	0.12

¹Multivariate model adjusted for age, physical activity, smoking, BMI, alcohol, energy, marital status, use of multivitamins, history of cardiovascular disease, history of hypercholesterolemia, history of hypertension, and history of diabetes. Q, quintile.