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. Author manuscript; available in PMC: 2017 Jan 27.
Published in final edited form as: Vaccine. 2015 Dec 20;34(5):643–649. doi: 10.1016/j.vaccine.2015.12.034

Figure 2. Serum bactericidal antibody responses of TG mice.

Figure 2

Panels A, B, and C: Meningococcal serogroup A, W, and X isolates, respectively, from cases of disease during epidemics in Africa. Panel D, a serogroup B isolate from The Gambia (675) and two serogroup C isolates from recent outbreaks in Northern Nigeria [12]. Bars represent the reciprocal median and ranges of the respective titers measured in serum pools (N=5 pools for MenB-4C, and 2 for NOMV-FHbp). Gray bars, TG mice immunized with MenB-4C; white bars, TG mice immunized with the NOMV-FHbp vaccine. All negative control sera from TG mice immunized with aluminum hydroxide without a vaccine antigen had titers <1:10 (data not shown). The two serogroup C isolates were killed by human complement and ≤0.5 μg/ml of a serogroup C anticapsular mAb.