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. 2016 Jan 30;2016:bav114. doi: 10.1093/database/bav114

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© The Author(s) 2016. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 2. — Interaction statistics for DOMMINO 2.0. (A) The growth of the number of binary macromolecular interactions in DOMMINO, from DOMMINO 1.0 (interactions between two polypeptide subunits only) to DOMMINO 2.0 (polypeptide-, DNA- and RNA-mediated interactions, shown in circles). The majority of interactions involving protein subunits are annotated using SUPERFAMILY (82% of inter-chain and 92% of intra-chain interactions). (B) Relative contribution of six most abundant interaction types involving a nucleotide subunit. Shown in the center are the total numbers of RNA- and DNA-mediated interactions. (C) Relative contribution of five most abundant polypeptide-polypeptide interaction types. Denoted are eight different subunits types: domains (D), C-termini (C), N-termini (N), inter-domain linkers (L), undefined chains (U), peptide (P), DNA molecules (DNA) and RNA molecules (RNA). Shown in the center is the total number of polypeptide-polypeptide interactions (PPIs).