Figure 4.

Human 3D interactome that includes RNA-, and DNA-mediated interactions. Shown is the largest connected component comprised of 39 399 protein subunits annotated into 354 SCOP protein families and mediating 26 516 protein–protein interactions and 257 protein–nucleotide interactions. The nodes correspond to protein families and are colored based on the types of interactions mediated by the proteins. Unstr corresponds to all unstructured protein subunits (C- and N-termini, and domain linkers). The numbers shown in the large nodes correspond to the SCOP IDs for those large protein families. For example, 48942 is a SCOP ID for the ‘C1 set domains (antibody constant domain-like)’ SCOP family of immunoglobulins.