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. 2015 Sep 14;11(2):263–271. doi: 10.1093/scan/nsv106

Fig. 2.

Fig. 2.

Trait optimism mediates the relationship between the OFC volume and anxiety. Presented here is the mediation model showing the significant negative indirect effect of trait optimism on the relation between the GMV in the left lOFC and anxiety. Path a refers to the relation from the predictor variable, X, to the mediator variable, M, and path b refers to the relation from M to the outcome variable, Y, while controlling for X. Path c refers to the total effect from X to Y, and path c′ refers to the direct effect from X to Y controlling for M. The indirect effects were represented by the interaction term a × b, and the significance of these effects was tested using bootstrapped 95% confidence intervals (CIs). Unstandardized regression coefficients are displayed. *P < 0.05; **P < 0.01.