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. Author manuscript; available in PMC: 2017 Feb 1.
Published in final edited form as: Brain Res. 2015 Dec 3;1632:34–41. doi: 10.1016/j.brainres.2015.11.044

Figure 1. Effects of SR-8993 on acquistion of cocaine CPP.

Figure 1

(A) Cocaine conditioned mice that received vehicle injections prior to each conditioning session showed robust CPP compared to saline conditioned mice. Naloxone significantly reduce cocaine CPP compared to vehicle. SR-8993 (3 mg/kg or 10 mg/kg) injections 30 min (A) or 2 h (B) before conditioning did not alter acquisition of CPP in mice conditioned with 15 mg/kg of cocaine. SR-8993 when injected (C) 30 min or (D) 2 h before conditioning did not change acquisition of CPP in mice conditioned with 7.5 mg/kg of cocaine. *p < 0.05, **p < 0.001 indicate a significant difference from vehicle via Newman-Keuls post hoc test (n = 6-9 per group). Data are mean ±SEM.