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. Author manuscript; available in PMC: 2016 Feb 1.
Published in final edited form as: Am J Transplant. 2015 Oct 20;16(2):574–582. doi: 10.1111/ajt.13495

Figure 1. Manhattan plot of single-nucleotide polymorphisms (SNPs) associated with tacrolimus trough concentrations.

Figure 1

Overall, 644 224 SNPs were analyzed toward natural log of dose-normalized tacrolimus trough concentrations (nanograms per milliliter per total daily dose in milligrams) with no additional covariates. All SNPs are shown in order from chromosome 1 to 22. The red line is at the level of statistical significance (p < 5 × 10−8). The major peak is above the CYP3A locus.