Table 5. Variance in natural log–transformed dose-normalized tacrolimus troughs in the discovery cohort.

Model	Variation of TAC troughs*	Variation explained by model**, %
Simple time-trend model	0.3114	–
Clinical variables	0.2497	19.8
Clinical variables + rs776746	0.1929	38.1
Clinical variables + rs10264272	0.2495	19.9
Clinical variables + rs41303343	0.231	25.8
Clinical variables + rs776746 and rs10264272	0.1845	40.7
Clinical variables + rs776746 and rs41303343	0.1553	50.1
Clinical variables + rs776746, rs10264272, and rs41303343	0.1436	53.9

^*Variance estimated for day 9 posttransplant natural log–transformed dose-normalized TAC trough concentration.

^**Proportion of variation explained by each model compared with the simple time-trend model, namely, 1–var/0.3114, in which var is the estimated variance for the day 9 random variable in the previous column.

TAC, tacrolimus.