Table 6. Variance in natural log–transformed dose-normalized tacrolimus troughs in the validation cohort.

Model	Variation of TAC troughs*	Variation explained by model**, %
Simple Time-trend Model	0.2806	–
Clinical Variables	0.2283	18.6
Clinical Variables + rs776746	0.213	24.1
Clinical Variables + rs10264272	0.2267	19.2
Clinical Variables + rs41303343	0.2224	20.7
Clinical Variables + rs776746 and rs10264272	0.2049	27.0
Clinical Variables + rs776746 and rs41303343	0.1976	29.6
Clinical Variables + rs776746, rs10264272, and rs41303343	0.1842	34.3

^*Variance estimated for day 9 posttransplant natural log–transformed dose-normalized TAC trough concentration

^**Proportion of variation explained by each model compared with the simple time-trend model, namely, 1–var/0.3114, in which var is the estimated variance for the day 9 random variable in the previous column.

TAC, tacrolimus.