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. 2016 Feb 8;8(4):231–262. doi: 10.4254/wjh.v8.i4.231

Table 3.

Effects of variceal ligation on frequency of portal hypertensive gastropathy

Ref. No. of patients and etiology Study type PHG rate before variceal ligation PHG aggravation after variceal ligation P value of pre vs post EVL
Hou et al[73] 90 patients with cirrhosis and recent variceal bleeding, 46 patients underwent EVL Randomized, controlled trial No PHG-4, mild PHG-33, severe-PHG-9 At eradication: 17/37; 17/37 (45.9%) in EVL; at 3 mo: 17/30 (56.7%); at 6 mo 18/29 (62.1%) P > 0.05
Elnaser et al[80] 125 patients with upper GI bleeding undergoing variceal ligation, followed for mean of 31 mo Retrospective study 22/125 (17.6%) 50/125 (50%) P < 0.05
Yüksel et al[41] 114 patients with cirrhosis and portal hypertension undergoing EVL in 85 patients Retrospective study 27/85 (31.8%) none; 28/85 (32.9%) mild; 30/85 (35.3%) severe 14/85 (16.5%) none; 30/85 (35.3%) mild; 41/85 (48.2%) severe P < 0.05
Lo et al[81] 77 patients with bleeding from EV underwent variceal ligation and were randomized to receive propranolol (37/77) or control (40/77); patients with severe PHG prior to treatment excluded from the study Prospective, randomized, controlled trial Control group: 7/40 (17%); propranolol group: 8/37 (22%) At variceal ligation: Control group: 67% (does not state number); Propranolol group: 31% (number not stated); 6 mo after treatment: Control group: 85% (number not stated) propranolol group: 48% (number not stated) Pre vs post ligation, both groups; P < 0.05; frequency of PHG significantly higher in control group post ligation when compared to propranolol group; P = 0.002
de la Peña et al[82] 93 patients with history of variceal hemorrhage and cirrhosis, randomized to receive either EVS (46/88) or EVL (42/88); 5 patients excluded due to diagnosis of hepatoma, non-cirrhotic portal hypertension or portal vein thrombosis Randomized, prospective study Not reported PHG significantly worsened in 23 patients, including 17 patients undergoing EVL P < 0.01

PHG: Portal hypertensive gastropathy; EVL: Endoscopic variceal ligation; EVS: Endoscopic variceal sclerotherapy.