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. Author manuscript; available in PMC: 2017 Feb 1.
Published in final edited form as: J Mol Endocrinol. 2016 Feb;56(2):R55–R71. doi: 10.1530/JME-15-0254

Figure 3.

Figure 3

Model of chromatin dynamics in ER mediated transcription. FoxA1 interacts with chromatin, providing access for ER to nearby EREs. ER then interacts with transcriptional co-activators and chromatin modifying enzymes to open up transcription start sites (TSS) for RNA polymerase II (PolII), allowing initiation of transcription. Reproduced, with permission, from Wall EH, Hewitt SC, Case LK, Lin CY, Korach KS & Teuscher C (2014) The role of genetics in estrogen responses: a critical piece of an intricate puzzle. FASEB Journal 28 5042–5054.