Table 1.

Estrogen Receptor Co-Regulator Complexes.

Complex	Functions	Comments	References
Src1, Src2, Src3	interact with Helix12 of agonist bound ER, interact with SWI/SNF, histone modifiers		(Hsia, et al. 2010; Johnson and O'Malley 2012)
Mediator	“bridges” ER and transcriptional “machinery” (RNA Pol II) to control transcription	made up of >20 subunits, MED 1-31, arranged in 3 modules (head, middle, tail)	(Conaway and Conaway 2011; Malik and Roeder 2010)
SWI/SNF	regulate access to enhancer sequences via chromatin remodeling, ATPase activity,	Made up of 9+ subunits, examples include BRG1, BRM, BAF subunits	(Roberts and Orkin 2004)
Histone Modifiers	Modify histones to increase or decrease transcription	Acetyltransferase (HAT;eg.p300/CBP), deacetyase (HDAC;eg.NCoR), Methyl transferase (eg.PMRT/CARM), demethylase	(Barnes, et al. 2005; Wu and Zhang 2009)
26S Proteasome	“clears” transcriptional modulatory proteins to facilitate subsequent transcription, transcriptional termination	Structure made up of 20S catalytic core particles (CP), 19S regulatory particles (RP)	(Keppler, et al. 2011; Kim, et al. 2011)

Reproduced, with permission, from Binder AK, Winuthayanon W, Hewitt SC, Couse JF & Korach KS (2015) Steroid receptors in the uterus and ovary. In Knobil and Neill's Physiology of Reproduction, 4th Edn, pp 1099–1193. Eds TM Plant & AJ Zeleznik. Elsevier.