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. Author manuscript; available in PMC: 2017 Jan 1.
Published in final edited form as: Biochim Biophys Acta. 2015 Oct 8;1865(1):14–22. doi: 10.1016/j.bbcan.2015.10.001

Figure 3. A role for senescence in age-related tumor development.

Figure 3

Senescent cells accumulate in tissues with age but little is known regarding the impact of this phenomenon on inflammation and cancer development. SASP factors can both promote and restrict tumor development through modulation of immune cells. The types of inflammation elicited by senescence in aging microenvironments as well as the consequence of this inflammation on tumorigenesis remain open questions.