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. Author manuscript; available in PMC: 2016 Jan 31.
Published in final edited form as: Eur J Endocrinol. 2013 Nov 29;170(1):151–160. doi: 10.1530/EJE-13-0740

Figure 3.

Figure 3

Schematic representation of the WT and Δ exons 3–6 mutant PRKAR1A genes and proteins. The genes are represented with exonic sequences (black and numbered) and intronic sequences (grey). The proteins are represented with their functional domains: dimerization domain (D/D); inhibitory sequence which binds to the catalytic subunit (IS); and the two cAMP-binding domains (A in dark grey and B in light grey) with their phosphobinding cassettes (PBC). The deleted mutant protein lacks the last four amino acids of the dimerization domain, the inhibitory sequence and the first 41 aminoacids of cAMP-binding domain A.