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Veins adjacent to MS lesions may cause non-local signal changes on HPF phase, complicating the interpretation of MS lesion-generated signal. For instance, the MS lesion identified on slice A of T2w (white arrow) appears shell-like on HPF phase but is not visible on QSM. However, inspection of neighboring slice B reveals an adjacent vein on HPF phase and QSM (black arrowhead) which may have generated the HPF phase signal change on slice A.
