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VRL concentrations after incubation of 100 nmol/l of substrate in HUVECs. Cells were exposed to VRL (100 nmol/l) for 24 h, as well as for the metronomic protocol of 96 h with daily medium change. Samples were collected at the end of the 24-h period. HUVEC, human umbilical vein endothelial cell; VRL, vinorelbine.
