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VRL on apoptosis and cell cycle. HUVECs were treated with VRL for 96 h (0.001, 0.1 and 1 nmol/l; metronomic model) or for 4 h, with a washout period of 92 h (10–1000 nmol/l; conventional chemotherapy). Percentages of (a) viable, total apoptotic and necrotic cells or (b) cells in cell-cycle phases in metronomic (left) versus conventional (right) chemotherapy were recorded. *P<0.05 compared with the control group. HUVEC, human umbilical vein endothelial cell; VRL, vinorelbine.
