Table 1.

Laboratory parameters of sickle cell disease patients before and after hydroxyurea treatment

Parameter	SCA	SCD-m	SS-α-thal	S-β-thal	Total
Hb (g/dl)
Before	10.0 ± 1.1	10.0 ± 1.6	9.9 ± 2.2	9.8 ± 1.1	10.0 ± 1.4
After	11.1 ± 1.0	10.5 ± 1.1	10.6 ± 1.2	10.9 ± 2.5	10.8 ± 1.2
	P < 0.0001*	P = 0.039	NS**	NS	P < 0.0001
Hct
Before	0.30 ± 0.03	0.32 ± 0.04	0.30 ± 0.07	0.31 ± 0.03	0.31 ± 0.04
After	0.33 ± 0.03	0.33 ± 0.04	0.33 ± 0.04	0.35 ± 0.05	0.33 ± 0.04
	P < 0.0001	NS	P = 0.033	NS	P < 0.0001
MCV (fl)
Before	87.9 ± 9.7	73.5 ± 6.0	76.2 ± 9.1	77.3 ± 11.6	80.9 ± 10.8
After	93.7 ± 9.3	81.2 ± 10	82.9 ± 12	86.0 ± 8.4	87.7 ± 11.2
	P = 0.002	P < 0.0001	P = 0.021	NS	P < 0.0001
MCH (pg)
Before	29.3 ± 3.6	23.7 ± 2.2	24.9 ± 3.6	24.3 ± 4.7	26.5 ± 4.1
After	31.4 ± 3.3	26.4 ± 3.8	27.0 ± 3.8	27.8 ± 3.0	29.0 ± 4.1
	P = 0.001	P = 0.001	NS	NS	P < 0.0001
MCHC (g/dl)
Before	33.2 ± 0.9	32.3 ± 0.8	32.6 ± 1.2	31.5 ± 1.2	32.7 ± 1.1
After	33.5 ± 0.9	32.5 ± 1.2	32.4 ± 0.7	32.3 ± 0.4	33.0 ± 1.1
	NS	NS	NS	NS	NS
RDW
Before	17.9 ± 3.5	16.5 ± 2.2	22.4 ± 7.7	19.3 ± 1.1	18.2 ± 4.2
After	15.9 ± 2.3	16.0 ± 1.7	16.1 ± 2.9	17.5 ± 1.3	16.1 ± 2.1
	P = 0.009	NS	NS	NS	P = 0.001
HbF (%)
Before	17.4 ± 6.0	14.5 ± 3.9	15.7 ± 3.3	11.7 ± 3.7	15.6 ± 5.1
After	21.3 ± 6.5	21.2 ± 8.6	19.3 ± 6.2	16.7 ± 2.8	20.1 ± 6.2
	P = 0.002	P = 0.004	NS	NS	P < 0.0001
HbS (%)
Before	77.9 ± 6.4	79.7 ± 4.8	79.0 ± 3.9	79.6 ± 3.5	78.7 ± 5.4
After	71.4 ± 6.2	71.2 ± 5.6	70.2 ± 6.3	71.2 ± 2.7	67.5 ± 13.6
	P < 0.001	P = 0.002	P = 0.01	P = 0.004	P < 0.0001
HbA2 (%)
Before	2.2 ± 1.9	3.3 ± 1.6	3.1 ± 1.6	7.4 ± 0.2	3.1 ± 2.2
After	2.4 ± 1.6	3.5 ± 2.1	3.1 ± 1.5	5.5 ± 3.7	3.2 ± 2.1
	NS	NS	NS	NS	NS

* P values represent results of paired t test

** NS, not significant (P > 0.05)