Table 3.
Univariate analysis of potential risk factors for development of cGVHD
| Group A—with cGVHD (n = 40) n (%) | Group B—no cGVHD (n = 37) n (%) | P value | |
|---|---|---|---|
| Patient related factors | |||
| Median age at transplant | 29 | 31 | 0.575 |
| Males | 28 (70) | 24 (65) | 0.631 |
| Diagnosis | 0.020 | ||
| Acute lymphoid leukemia (ALL) | 17 (43) | 6 (16) | |
| Acute myeloid leukemia (AML) | 23 (58) | 29 (78) | |
| Biphenotypic leukemia | 0 (0) | 2 (5) | |
| Baseline risk | 0.138 | ||
| Good (or standard) risk | 2 | 4 | |
| Intermediate risk | 7 | 14 | |
| Poor risk | 25 | 14 | |
| Not known | 6 | 5 | |
| Relapse/refractory disease at transplant | 5 (12) | 10 (27) | 0.231 |
| Donor related factors | |||
| Median donor age, years | 32 | 33 | 0.860 |
| ABO mismatch transplants | 20 (50) | 12 (32) | 0.118 |
| Gender mismatched transplants | 25 (63) | 15 (41) | 0.054 |
| Female to male transplants | 17 (43) | 6 (16) | 0.012 |
| Stem cell source | 0.855 | ||
| Bone marrow | 2 (5) | 3 (8) | |
| Umbilical cord | 1 (3) | 1 (3) | |
| Peripheral blood stem cells | 37 (93) | 33 (89) | |
| Degree of HLA matching | 0.121 | ||
| BM or PBSC | |||
| Full matched (6/6 or 10/10) | 34 (85) | 27 (73) | |
| 1 antigen mismatch | 5 (13) | 4 (11) | |
| Haplo-identical transplant | 0 (0) | 5 (14) | |
| Cord transplants | 1 (3) | 1 (3) | |
| Transplant related factors | |||
| Type of transplant | 0.321 | ||
| Matched related transplant | 35 (88) | 30 (81) | |
| Matched unrelated transplant | 5 (13) | 5 (14) | |
| Haplo-identical transplant | 0 (0) | 2 (5) | |
| Type of conditioning regimen | 0.093 | ||
| Full intensity | 18 (45) | 9 (24) | |
| Reduced intensity | 22 (55) | 28 (76) | |
| Total body irradiation used | 20 (50) | 12 (32) | 0.118 |
| ATG used | 5 (13) | 7 (19) | 0.438 |
| Graft versus host disease prophylaxis | 0.224 | ||
| CsA+MTX | 30 (75) | 23 (62) | |
| CsA+MMF | 10 (25) | 14 (38) | |
| Cell doses infused | |||
| TNC (×108)/kg | 7.10 | 6.63 | 0.913 |
| CD34 (×106)/kg | 5.11 | 5.12 | 0.899 |
| CD3 (×106)/kg | 147.80 | 177.65 | 0.039 |
| Prior acute GVHD, any grade, n (%) | 21 (53) | 13 (35) | 0.630 |
| Day100 median absolute lymphocyte count (×109/L) | 1.23 (n = 39) | 1.41 (n = 28) | 0.589 |
| Day180 median absolute lymphocyte count (×109/L) | 1.61 (n = 39) | 2.05 (n = 22) | 0.131 |