Table 2.
Upper limit of normal (ULN), 97.5 % percentiles and cutoffs for autoantibody (autoAb) testing to tissue transglutaminase 2 (TG2)
| ULN (U/mL) | 97.5 % percentile (U/mL) | Cutoff (U/mL) | |
|---|---|---|---|
| ED (n = 68) | 1.65 | 1.94 | 3.91a |
| BD (n = 91) | 1.15 | 1.42 | 1.71b |
| ED + BD (n = 159) | 1.41 | 1.54 | 3.91c |
TG2autoAb were determined by CytoBead CeliAK in 130 pediatric/adolescent patients with celiac disease (CD) (<18 years) and 24 adult patients (≥18 years) as well as pediatric patients with eye disease (ED) and blood donors (BD) and subjected to receiver operating characteristics curve analysis. ULN (mean + 2 standard deviations), 97.5 % percentiles, and cutoffs were calculated. Total sample numbers can differ due to lack of human material or assay failure
aROC: CD <18 years vs ED
bROC: CD ≥18 years vs BD
cROC: CD vs ED + BD