Table 2.
List of 38 ME-markers that are significantly associated with both the linear change in perceived parental rejection (PARQ-slope) and psychosocial adjustment (BASC-CV, personal adjustment composite).
| ME-marker, start position | Regression coefficients | Genome Annotation | ||
|---|---|---|---|---|
|
| ||||
| β | p-value | Gene/Locus | GO: Biological Process | |
|
| ||||
| chr1:33998550 | -.461 | .039 | CSMD2 | integral to membrane |
| chr1:113202150 | -.513 | .080 | CAPZA1 | cell motion, cytoskeleton organization; actin filament-based process |
| chr1:203954250 | -.473 | .039 | TF binding site | |
| chr2:4183550 | -.502 | .030 | ||
| chr2:11147750 | -.555 | .030 | ||
| chr2:54325850 | -.544 | .030 | ACYP2 | phosphate-containing compound metabolic process |
| chr2:125652050 | -.518 | .056 | CNTNAP5 | cell adhesion |
| chr3:183525750 | -.676 | .030 | YEATS2-AS1 | |
| chr3:196318950 | -.634 | .035 | ||
| chr4:1198750 | -.480 | .031 | SPON2 | cell morphogenesis; cell motion; immune response; cell adhesion; axonogenesis |
| chr4:76533250 | -.469 | .044 | CDKL2 | protein phosphorylation; signal transduction; reproductive developmental process |
| chr6:170496250 | -.665 | .030 | ||
| chr7:27141650 | -.523 | .030 | HOXA2 | regulation of transcription; cell morphogenesis; cell motion; axonogenesis; neuron differentiation |
| chr7:100843550 | -.684 | .000 | MOGAT3 | glycerol, alditol and polyol metabolic process; lipid biosynthetic process |
| chr7:101454050 | -.638 | .030 | ||
| chr7:130522550 | -.291 | .208 | ||
| chr8:108555250 | -.492 | .030 | ||
| chr8:123888850 | -.621 | .029 | ZHX2 | regulation of transcription, mRNA catabolic process; regulation of neuron differentiation |
| chr8:142389850 | -.534 | .030 | lncRNA | |
| chr9:99251950 | -.659 | .030 | HABP4 | regulation of transcription; platelet degranulation and activation; blood coagulation |
| chr9:140928850 | -.557 | .091 | CACNA1B | calcium ion transport; synaptic transmission; neurotransmitter secretion; locomotory behavior |
| chr10:88476150 | -.492 | .039 | LDB3 | muscle alpha-actinin binding; zinc ion binding |
| chr11:1673750 | -.477 | .030 | MOB2 | stimulates the autophosphorylation and kinase activity of STK38 and STK38L |
| chr11:69269150 | -.479 | .033 | ||
| chr13:49796550 | -.580 | .030 | ||
| chr13:10823895 | -.496 | .030 | FAM155A | |
| chr14:10404775 | -.506 | .030 | APOPT1; | intrinsic apoptotic signaling pathway |
| KLC1 | microtubule motor activity and tubulin binding | |||
| chr16:88448350 | -.480 | .030 | ||
| chr17:64550 | -.492 | .031 | RPH3AL | exocytosis; response to drug; glucose homeostasis; regulation of G-protein signaling pathway |
| chr17:4755050 | -.660 | .019 | MINK1 | protein phosphorylation; intracellular signaling cascade; synaptic transmission; cell-cell adhesion |
| chr17:43309250 | -.601 | .030 | FMNL1 | substrate-dependent cell migration; regulation of cell shape; cortical actin cytoskeleton organization |
| chr17:75864350 | -.504 | .030 | ||
| chr18:61489650 | -.568 | .030 | ||
| chr19:55813850 | -.483 | .039 | BRSK1 | intracellular signaling cascade, neurotransmitter secretion; neuron morphogenesis; axonogenesis |
| chr20:47087850 | -.505 | .030 | TF binding site | |
| chr21:44715450 | -.487 | .064 | TF binding site | |
| chr22:36874350 | -.598 | .030 | TXN2 | electron transport chain; response to internal and external stimulus; response to axon injury |
| chr22:50422050 | -.546 | .030 | TF binding site | |
Notes. ME-markers are presented in the order of their genomic localization. The EWAS showed that all 38 ME-markers were significantly associated with the PARQ-slope and the BASC-CV personal adjustment composite. A series of regression analyses was performed to test the modulating role of these markers in the relationship between the PARQ-slope and the BASC-CV personal adjustment composite. Regression coefficients and p-values (adjusted for multiple comparisons using FDR method) for the 38 ME-markers were estimated in 38 separate regressions of the BASC-CV personal adjustment composite on one ME-marker and the PARQ slope, controlling for age, gender and the number of SRAD and psychiatric problems. p-values > .05 are italicized. Genes directly related to CNS development and functioning, as defined by GO categories, are marked in bold.