1. Primary analysis data including deaths and missing cases.
| Study | Photocoagulation | Observation | Risk of bias due to incomplete outcome data | ||||||
| F | S | D | M | F | S | D | M | ||
| CAPT | 41 | 967 | 25 | 19 | 50 | 958 | 25 | 19 | Low (bilateral) |
| CNVPT | 12 | 34 | 2 | 11 | 13 | 34 | 3 | 11 | Low |
| DLS bilateral | 12 | 91 | 0 | 2 | 7 | 96 | 0 | 2 | Low (bilateral) |
| DLS unilateral | 27 | 72 | 0 | 0 | 15 | 70 | 0 | 0 | Low |
| Figueroa 1994 | 0 | 30 | 0 | 0 | 1 | 29 | 0 | 0 | Low (bilateral) |
| Frennesson 1995 | 0 | 17 | 0 | 2 | 4 | 15 | 0 | 0 | Low |
| Frennesson 2009 | 7 | 67 | NA | NA | 5 | 68 | NA | NA | Low (see Results) |
| Laser to Drusen Study 1995 | 6 | 34 | 0 | 7 | 11 | 31 | 0 | 10 | Low |
| Little 19951 | 3 | 24 | NA | NA | 5 | 22 | NA | NA | Low (bilateral) |
| Olk 1999 bilateral | 3 | 28 | 2 | 10 | 3 | 62 | 4 | 5 | Low (bilateral) |
| Olk 1999 unilateral2 | 4 | 17 | NA | 6 | 7 | 19 | NA | 4 | Low |
| PTAMD bilateral 2009 | 24 | 197 | NA | 419 | 20 | 200 | NA | 419 | Low (bilateral) |
| PTAMD unilateral 20023 | 13 | 50 | 5.5 | 55.5 | 9 | 62 | 5.5 | 43.5 | High |
The assessment of the risk of bias due to incomplete outcome data is based on the graphical presentation in Figure 1 based on the methods described in Appendix 8. In the updated version of this review, we considered missing data as at no risk of bias in bilateral studies because a participant with paired treatment and control eyes is missed.
F: failures (choroidal neovascularisation development), S: successes, D: deaths, M: missing of unknown cause, NA: not available.
1Only last visit follow‐up available and no information on when choroidal neovascularisation developed in cases with event. 2Deaths were not reported and all missing data were coded as missing of unknown cause. 3Deaths were provided overall (n = 11 at 2 years) and were equally split between assignment groups. Data at 1 or 3 years were available and midpoints were used.