Table II.
Univariate analysis of variables correlated with ≥4 lymph node metastases.
| LN metastases, no. (%) | |||
|---|---|---|---|
| Variables | <4 (n=103) | ≥4 (n=31) | P-value |
| Menopausal status | 0.177 | ||
| Premenopausal | 36 (70.6) | 15 (29.4) | |
| Postmenopausal | 67 (80.7) | 16 (19.3) | |
| Clinical T classification | 0.010 | ||
| cT1 | 57 (86.4) | 9 (13.6) | |
| ≥cT2 | 46 (67.6) | 22 (32.4) | |
| Clinical N classification | 0.006 | ||
| cN0 | 52 (88.1) | 7 (11.9) | |
| cN1 suspected | 51 (68.0) | 24 (32.0) | |
| ER status | 0.909 | ||
| + | 84 (77.1) | 25 (22.9) | |
| − | 19 (76.0) | 6 (24.0) | |
| PR status | 0.910 | ||
| + | 72 (76.6) | 22 (23.4) | |
| − | 31 (77.5) | 9 (22.5) | |
| HER2 status | 0.102 | ||
| + | 19 (65.5) | 10 (34.5) | |
| − | 84 (80.0) | 21 (20.0) | |
| TTL (copies/µl) | 0.001 | ||
| <5.4×104 | 61 (88.4) | 8 (11.6) | |
| ≥5.4×104 | 42 (64.6) | 23 (35.4) | |
| Ki-67 | 0.144 | ||
| <20% | 39 (84.8) | 7 (15.2) | |
| ≥20% | 25 (71.4) | 10 (28.6) | |
| Histological grade | 0.339 | ||
| ≤2 | 53 (80.3) | 13 (19.7) | |
| 3 | 17 (70.8) | 7 (29.2) | |
| SLN ratio | 0.103 | ||
| <0.67 | 34 (91.9) | 3 (8.1) | |
| ≥0.67 | 69 (71.1) | 28 (28.9) | |
| Lymphovascular invasion | 0.063 | ||
| No | 45 (84.9) | 8 (15.1) | |
| Yes | 56 (70.9) | 23 (29.1) | |
LN, lymph node; ER, estrogen receptor; PR, progesterone receptor; HER2, human epidermal growth factor receptor 2; SLN, sentinel lymph node; TTL, total tumor load.