Figure 2.

Open field test was used to investigate the effects of ibuprofen on anxiety and locomotion in an AlCl₃-induced mouse model of neurotoxicity. The control and ibuprofen-treated groups spent significantly less time in the periphery and more time in the central area, as compared with the AlCl₃-treated group. Data are presented as the mean ± standard error of the mean (n=10/group). The test was performed on day 12 following the start of treatment with the drugs. The time spent in the periphery and center of the chamber was calculated. ***P<0.001 vs. the AlCl₃-treated group. Ibp, ibuprofen; AlCl₃, aluminum chloride.