Table III.
Correlation of DLC-1 methylation and mRNA and protein expression with clinical and histological variables in NSCLC patients.
| Methylation | mRNA | Protein | ||||||
|---|---|---|---|---|---|---|---|---|
| Characteristics | Present | Absent | P-value | (mean ± SE) | P-value | Normal | Reduced | P-value |
| Age (years) | 1 | 0.502 | 1 | |||||
| <60 | 9 | 2 | 24.6±7.3 | 4 | 7 | |||
| ≥60 | 14 | 5 | 19.0±4.7 | 7 | 12 | |||
| Smoking index | 0.024 | 0.042 | 0.442 | |||||
| <400 | 12 | 0 | 30.7±6.7 | 3 | 9 | |||
| ≥400 | 11 | 7 | 14.6±4.3 | 8 | 10 | |||
| Histological type | 0.071 | 0.399 | 0.432 | |||||
| Adenocarcinoma | 6 | 5 | 16.5±6.5 | 5 | 6 | |||
| SCC | 16 | 2 | 23.8±5.3 | 5 | 13 | |||
| TNM stage | 0.657 | 0.592 | 0.425 | |||||
| I/II | 16 | 4 | 19.5±4.5 | 6 | 14 | |||
| III | 7 | 3 | 24.1±7.8 | 5 | 5 | |||
| Differentiation | 1 | 0.883 | 1 | |||||
| High/moderate | 3 | 0 | 19.2±7.4 | 1 | 2 | |||
| Poor/undifferentiated | 20 | 7 | 21.2±4.3 | 10 | 17 | |||
DLC-1, deleted in liver cancer-1; NSCLC, non-small-cell lung carcinoma; SCC, squamous cell carcinoma; SE, standard error; TNM, tumor node metastastis.