Table I.
Clinicopathological characteristics and immunohistochemical profile of the present and previously reported cases.
| (Refs.) | Cases, n | Age, years/gender | Clinical presentation | Tumor size, cm | Location | pTNM | Follow-up, months | Negative immunohistochemical markers | Positive immunohistochemical markers |
|---|---|---|---|---|---|---|---|---|---|
| (4) | 1 | 39/F | Abdominal pain | 1.5 | Right kidney/lower pole | pT1aN0 | 18 | CD15 | TG, estrogen receptor |
| (5) | 6 | 53/F | Incidental | 2.1 | Right kidney/mid-pole | pT1aNx | 54 | PAX-2, RCC, CD10, WT-1, | CK7 (1 case) |
| 29/F | Incidental | 1.9 | Right kidney/upper pole | pT1aNx | 84 | Ksp-cadherin, α-methyl-CoA | |||
| 45/M | Incidental | 3.5 | Right kidney/lower pole | pT1aN1 | 17 | racemase, vimentin, CD56, | |||
| 83/M | Incidental | 2.1 | Left kidney/lower pole | pT1aNx | 48 | CD57, TG, TTF-1 | |||
| 35/M | Incidental | 3.0 | Right kidney/mid-pole | pT1aNx | 20 | ||||
| 50/F | Incidental | 4.0 | Right kidney/mid-pole | pT1aN0 | 7 | ||||
| (6) | 1 | 32/F | Incidental | 11.8 | Right kidney/lower and mid-pole | pT2Nx | 6 | CK, 34βE12, CK7, CK19, CK20, CD15, EMA, CEA, TG, TTF-1 | CK, AE1/AE3, CD10, CK 35βH11 (focal), vimentin (focal) |
| (7) | 1 | 31/F | Flank pain, weight loss and gross hematuria | 4.0 | Left kidney/upper and mid-pole | pT1aN0 | 21 | CK20, CD10, TG, TTF-1, α-methyl-CoA racemase, | CK, AE1/AE3, CK7, CK19, vimentin, RCC, galectin-3, HBME-1, PAX-2 |
| (8) | 1 | 34/F | Gross hematuria, right flank pain | 6.2 | Right kidney/mid-pole | pT1bN2M1 | 3 | CK20, TG, TTF-1, CD10, CD117, RCC, CEA, WT-1, α-methy-CoA racemase, p63 | In the lungs: PAX-2, PAX-8, CK7, CK5, vimentin, EMA, N-cadherin; in the kidneys PAX-2, vimentin, CK7 |
| (9) | 1 | 29/F | Incidental | 5.0 | Left kidney/mid-pole | pT1bNoM1 | 60 | CD10, CD117, TG, TTF-1 | CAM 5.2, CK7, CK20, vimentin |
| (10) | 2 | 76/M | Gross hematuria | 4.5 | Left kidney/upper pole | pT1bN0 | 11 | CK20, CD10, RCC, CEA, WT-1, | CK7, CK19, EMA, vimentin, |
| 41/F | Incidental | 4.3 | Right kidney/lower pole | pT1bNx | 4 | chromogranin, Syn, CD56, NSE, TG, TTF-1, galectin-3, HBME-1, Ulex europaeus lectin | 34βE12 (focal), E-cadherin (focal) | ||
| (11) | 1 | 29/F | Abdominal pain | 6.5 | Left kidney/lower pole | pT1bN0M0 | 4 | TTF-1, CD117, CK20, TG | EMA, vimentin, CD10 (focal), CK7 (focal) |
| (12) | 1 | 26/F | Incidental | 4.0 | Right kidney/upper and mid-pole | pT1aNxMx | Unknown | TTF-1, TG, TPO, CK20, RCC, ER, PR, WT-1, CAM 5.2, CK7, CD57, CD56, Syn, CgA | CK AE1/AE3, CAM 5.2, CK7, vimentin, CD10 (weakly), EMA (focal) |
| (13) | 1 | 34/M | Left flank pain | 5.5 | Left kidney/lower pole | pT1bNx | 6 | RCC, CD10, CD15, CD56, CD117, CEA, CK20, TFE3, TG, TTF-1, WT-1 | CAM5.2, P504S, vimentin, CK7, CK34β12, EMA, CK AE1/AE3, |
| (14) | 1 | 36/F | Gross hematuria | 10.0 | Left kidney | pT2N1M0 | 12 | RCC, CD117, TTF-1, TG, WT-1, CgA, Syn | EMA, vimentin, CK7, CD10 (focal), CD15 (focal), CD99 (focal) |
| (15) | 1 | 22/F | Gross hematuria | 8.0 | Left kidney | pT2N0M0 | Unknown | TG, TTF-1, vimentin, CD63, P63 | CKpan, CK19, EMA, CK7 (focal), CK20 (focal), NSE (focal), Syn (focal) |
| (16) | 1 | 66/M | Gross hematuria, right flank pain | 8.0 | Right kidney | pT3aN0 | 20 | TG, TTF-1, WT-1, CD117, AMACR, 34BE12, Syn, CK20, CD56, CD34, CD57, CD99, CD15 | Ckpan, vimentin, EMA, NSE, CK7 (focal), CK19 (focal) |
| (17) | 1 | 68/F | Relapsing urinary infection | 1.1 | Right kidney/mid pole | pT1aN0M0 | 6 | CD10, 504 s protein, TTF-1, TG | EMA, CK7 (focal), CK19, CKAE1/AE3 (focal), CK34Be 12 (focal), vimentin, CD117 |
| (18) | 1 | 19/F | Abdominal pain | 2.0 | Right kidney/lower pole | pT3aN0M0 | 21 | TTF-1, TG, CD10, CD56, WT-1, SMMHC, CEA, S-100 | CK7, AE1/AE3, EMA, PAX-2, PAX-8B |
| (19) | 2 | 65/M | Hematuria and right back pain | 8.0 | Right kidney/middle-lower pole | pT2N0M0 | 15 | CK20, CK10, TTF-1, TG, | CK7 (focal), CK19, EMA, |
| 59/M | Incidental | 5.2 | Right kidney/middle-lower pole | pT1aN0M0 | 1 | TTF-1, TG | CK7, CK20, EMA | ||
| Present | 3 | 35/F | Incidental | 2.8 | Left kidney/lower and mid-pole | pT1aN0M0 | 14 | CD10, CK7, CD68, TG, TTF-1 | CK, CK18, CK19, vimentin |
| 38/M | Gross hematuria, left flank pain | 6.0 | Left kidney/upper and mid-pole | pT3aN0M0 | 17 | TTF-1, TG | CK7 | ||
| 25/F | Incidental | 2.5 | Right kidney/upper pole | pT1aN0M0 | 24 | CD117, TTF-1, TG, CgA, Syn | EMA, vimentin, CK7, CK20 |
M, male; F, female; CD, cluster of differentiation; PAX-2, paxillin-2; RCC, renal cell carcinoma; WT-1, Wilms' tumor gene 1; TG, thyroglobulin; TTF-1, thyroid transcription factor-1; CK, cytokeratin; CEA, carcinoembryonic antigen; EMA, epithelial membrane antigen; HBME, human bone marrow endothelial; Syn, synaptophysin; NSE, neuron-specific enolase; CAM 5.2, cell adhesion molecule 5.2; AMACR, α-methylacyl-CoA racemase; SMMHC, smooth muscle myosin heavy chain.