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. 2015 Dec 3;11(2):1089–1094. doi: 10.3892/ol.2015.3997

Figure 2.

Figure 2.

Correlation between MVD and metastasis demonstrated in mouse models. (A) Association between MVD and the expression levels of TGFβ1 mRNA, Smad2 mRNA, Smad7 mRNA, VEGF and TGFβ1 protein. Error bars represent the standard error of the mean. *Statistically significant difference between two groups (P<0.05). (B) Correlation between VEGF and TGFβ1 protein. (C) Correlation between TGFβ1 protein and the tumor foci number of pulmonary metastasis. (D) Correlation between VEGF protein and the tumor foci number of pulmonary metastasis. Dots represent all samples, and the line denotes a regression line. MVD, microvessel density; TGF, transforming growth factor; mRNA, messenger RNA; VEGF, vascular endothelial growth factor; OD, optical density.