Table IV.
Prognostic factors of OS in patients with HCC >10 cm.
| Univariate | Multivariate | |||||
|---|---|---|---|---|---|---|
| Variable | HR | 95% CI | P-value | HR | 95% CI | P-value |
| Age, years | ||||||
| >48 vs. ≤48 | 0.770 | 0.527–1.125 | 0.175 | |||
| Gender | ||||||
| Male vs. female | 1.829 | 0.889–3.761 | 0.096 | |||
| HBsAg | ||||||
| Positive vs. negative | 1.530 | 0.932–2.513 | 0.090 | |||
| Cirrhosis | ||||||
| Yes vs. no | 1.349 | 0.887–2.052 | 0.161 | |||
| Tumor encapsulation | ||||||
| None vs. complete | 1.887 | 1.274–2.795 | 0.001 | 1.276 | 0.824–1.976 | 0.274 |
| Tumor no. | ||||||
| Multiple vs. solitary | 1.374 | 0.939–2.011 | 0.100 | |||
| Vascular invasion | ||||||
| Present vs. absent | 2.768 | 1.777–4.310 | <0.001 | 2.363 | 1.486–3.759 | <0.001 |
| Differentiation | ||||||
| III–IV vs. I–II | 2.194 | 1.453–3.312 | <0.001 | 2.179 | 1.406–3.375 | <0.001 |
| TNM stage | ||||||
| II–III vs. I | 1.579 | 1.074–2.323 | 0.019 | |||
| AFP, µg/l | ||||||
| >25 vs. ≤25 | 1.493 | 0.989–2.255 | 0.055 | |||
| GGT, U/l | ||||||
| >50 vs. ≤50 | 1.469 | 0.987–2.186 | 0.056 | |||
| HGB, g/l | ||||||
| ≤110 vs. >110 | 0.961 | 0.548–1.686 | 0.889 | |||
| MCH, pg | ||||||
| ≤27 vs. >27 | 1.931 | 1.224–3.049 | 0.004 | 2.222 | 1.361–3.636 | 0.001 |
OS, overall survival; HCC, hepatocellular carcinoma; HR, hazard ratio; CI, confidence interval; HBsAg, hepatitis B surface antigen; TNM, tumor-node-metastasis; AFP, α-fetoprotein; GGT, γ-glutamyl transpeptidase; HGB, hemoglobin; MCH, mean corpuscular hemoglobin.