FIG 6.

Endothelium-platelet interaction in a mouse model of influenza virus-induced lung injury. (A) Lung histology showing that influenza infection is associated with increased platelet deposition in murine lungs. Platelets shown by DAB staining are labeled using an anti-CD41 antibody. Control group, n = 3 animals; flu group, n = 5 animals. (B) Immunostaining for fibronectin reveals increased fibronectin deposition on the lung endothelium of influenza-infected mice compared to that of uninfected controls. Fibronectin is stained green. Control group, n = 3 mice; flu group, n = 5 mice. In all experiments, images are representative of 10 (×200 magnification) fields per lung. *, P < 0.05.