FIG 5.
Abortive RABV infection of astrocytes. (A) Cartoon showing Cre recombinase-expressing RABV and predicted Cre-mediated deletion of a STOP cassette in Tomatoflox mice. (B and C) tdTomatoflox mice were infected with 105 PFU of Cre recombinase-encoding RABV. At day 6 postinfection, brain slices were analyzed for expression of tdTomato (B) and RABV-N antigen (C). A section of the hippocampus is shown. (D) Double staining showed that dtTomato-positive cells in the boxed areas of panels B and C represent GFAP-positive astrocytes. Bar = 20 μm.