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. 2015 Dec 3;11(2):925–932. doi: 10.3892/ol.2015.3990

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Copyright: © Zhao et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 4. — Effect of IL-6 inhibition on aggressive tumor behavior and epithelial-mesenchymal transition changes. (A) Effect of IL-6 inhibition on the migration/invasive ability of esophageal cancer cells (KYSE170 and TE13), as measured by a scratch assay. Images of the plates were captured at the times indicated. (B) The migration ability of esophageal cancer cells with or without the IL-6 silencing vector was evaluated by murine orthotopic tumor implantation. (C) E-cadherin levels in cells were evaluated by immunofluorescence assay. The immunofluorescent colors are as follows: Blue, DAPI; green, GFP; red, E-cadherin. (D) The invasive capacity of cancer cells as determined by cell invasion assay; representative slides and quantitative data are shown. Slides represent KYSE170-IL-6 silencing vector-treated mice (right) and TE13-IL-6 silencing vector-treated mice (left). IL-6, interleukin 6; GFP, green fluorescent protein.