Table II.
Primary information for IL-18 rs360719 A>G, IL-18R1 rs13015714 G>T, IL-18RAP rs917997 C>T and IL-28B rs8099917 T>G polymorphisms.
| Genotyped SNPs | IL-18 rs360719 A>G | IL-18R1 rs13015714 G>T | IL-18RAP rs917997 C>T | IL-28Brs8099917 T>G |
|---|---|---|---|---|
| Chromosome | 11 | 2 | 2 | 19 |
| Location | 5′-Flanking | 5′-Flanking | 3′-Flanking | 5′-Flanking |
| Chr Pos (genome build 36.3) | 111541359 | 102338297 | 102437000 | 44435005 |
| Regulome DB scorea | 2b | 6 | No data | 4 |
| TFBSb | Y | – | – | – |
| MAFc for Chinese population | 0.142 | 0.547 | 0.488 | 0.035 |
| MAF in the controls (n=380) | 0.134 | 0.511 | 0.496 | 0.049 |
| P-value for HWEd test in our controls | 0.774 | 0.249 | 0.465 | 0.325 |
| Genotyping value, % | 96.97 | 96.45 | 96.32 | 97.11 |
b
TFBS, transcription factor binding site (http://snpinfo.niehs.nih.gov/snpinfo/snpfunc.htm);
c
MAF, minor allele frequency; IL-18 rs360719 A>G MAF information was available for the Chinese Han and Japanese populations;
d
HWE, Hardy-Weinberg equilibrium. SNPs, single-nucleotide polymorphisms; IL-18, interleukin-18; IL-18R1, IL-18 receptor 1; IL-18RAP, IL-18 receptor accessory protein; Chr Pos, chromosome position; Y, yes.