Table III.
Logistic regression analyses of the associations between IL-18 rs360719 A>G, IL-18R1 rs13015714 G>T, IL-18RAP rs917997 C>T and IL-28B rs8099917 T>G polymorphisms and the risk of ESCC.
| Genotype | Casesn (n=380), (%) | Controls (n=380), n (%) | Crude OR (95% CI) | P-value | Adjusted ORa (95% CI) | P-value |
|---|---|---|---|---|---|---|
| IL-18 rs360719 A>G | ||||||
| AA | 267 (72.6) | 276 (74.8) | 1.00 | 1.00 | ||
| AG | 97 (26.4) | 87 (23.6) | 1.15 (0.83–1.61) | 0.406 | 1.15 (0.82–1.62) | 0.411 |
| GG | 4 (1.1) | 6 (1.6) | 0.69 (0.19–2.47) | 0.568 | 0.68 (0.19–2.46) | 0.553 |
| GG vs. AG vs. AA | 0.579 | |||||
| AG+GG | 101 (27.4) | 93 (25.2) | 1.12 (0.81–1.56) | 0.490 | 1.12 (0.81–1.56) | 0.498 |
| AA+AG | 364 (98.9) | 363 (98.4) | 1.00 | 1.00 | ||
| GG | 4 (1.1) | 6 (1.6) | 0.67 (0.19–2.38) | 0.530 | 0.65 (0.18–2.37) | 0.517 |
| G allele | 105 (14.3) | 99 (13.4) | ||||
| IL-18R1 rs13015714 G>T | ||||||
| GG | 100 (27.5) | 83 (22.4) | 1.00 | 1.00 | ||
| GT | 173 (47.7) | 196 (53.0) | 0.73 (0.51–1.05) | 0.086 | 0.71 (0.49–1.02) | 0.060 |
| TT | 90 (24.8) | 91 (24.6) | 0.82 (0.54–1.24) | 0.348 | 0.83 (0.54–1.25) | 0.364 |
| TT vs. GT vs. GG | 0.229 | |||||
| GT+TT | 263 (72.5) | 287 (77.6) | 0.76 (0.54–1.06) | 0.110 | 0.75 (0.53–1.05) | 0.089 |
| GG+GT | 273 (75.2) | 279 (75.4) | 1.00 | 1.00 | ||
| TT | 90 (24.8) | 91 (24.6) | 1.01 (0.72–1.41) | 0.950 | 1.04 (0.74–1.46) | 0.829 |
| T allele | 353 (48.6) | 378 (51.1) | ||||
| IL-18RAP rs917997 C>T | ||||||
| CC | 91 (25.0) | 90 (24.5) | 1.00 | 1.00 | ||
| CT | 167 (45.9) | 191 (51.9) | 0.87 (0.61–1.24) | 0.426 | 0.84 (0.58–1.20) | 0.334 |
| TT | 106 (29.1) | 87 (23.6) | 1.21 (0.80–1.81) | 0.369 | 1.19 (0.79–1.80) | 0.404 |
| TT vs. CT vs. CC | 0.177 | |||||
| CT+TT | 273 (75.0) | 278 (75.5) | 0.97 (0.69–1.36) | 0.865 | 0.95 (0.67–1.33) | 0.753 |
| CC+CT | 258 (70.9) | 281 (76.4) | 1.00 | 1.00 | ||
| TT | 106 (29.1) | 87 (23.6) | 1.33 (0.95–1.85) | 0.093 | 1.34 (0.96–1.87) | 0.085 |
| T allele | 379 (52.1) | 365 (49.6) | ||||
| IL-28B rs8099917 T>G | ||||||
| TT | 335 (91.0) | 334 (90.3) | 1.00 | 1.00 | ||
| TG | 31 (8.4) | 36 (9.7) | 0.86 (0.52–1.42) | 0.553 | 0.87 (0.52–1.44) | 0.585 |
| GG | 2 (0.5) | 0 (0.0) | – | 0.980 | – | 0.980 |
| GG vs. TG vs. TT | 0.306 | |||||
| TG+GG | 33 (9.0) | 36 (9.7) | 0.91 (0.56–1.50) | 0.722 | 0.92 (0.56–1.52) | 0.741 |
| TT+TG | 366 (99.5) | 370 (100) | 1.00 | 1.00 | ||
| GG | 2 (0.5) | 0 (0.0) | – | 0.980 | – | 0.980 |
| G allele | 35 (4.8) | 36 (4.9) |
a
Adjusted for age, gender, smoking status and alcohol consumption. IL-18, interleukin-18; IL-18R1, IL-18 receptor 1; IL-18RAP, IL-18 receptor accessory protein; ESCC, esophageal squamous cell carcinoma; OR, odds ratio; CI, confidence interval.